Table 3. Profiling of Compound 31^a.

solubility (pH = 7.4) (μM)	98
Caco-2 Papp (10–6 cm/s)	18.8
human hepatocytes Clint (μL/min/10–6 cells)	1.7
sPLA2-X IC50 (μM)	0.026
sPLA2-X mouse IC50 (μM)	0.096
sPLA2-IIa IC50 (μM)	0.31
sPLA2-V IC50 (μM)	2.23
pharmacokinetics	rat	dog
dose i.v./p.o. (μmol/kg)	1/4	1/–
CL (mL/min/kg)	9.1	0.75
AUC (μM·h)	1.84/11	8.78/–
Vdss (L/kg)	2.54	0.44
F (%)	100

^aSee Supporting Information for experimental details