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. 2018 Jul 9;9:1575. doi: 10.3389/fimmu.2018.01575

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Copyright © 2018 Álvarez-Rodríguez, Pereiro, Reyes-López, Tort, Figueras and Novoa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Ifng1-2 on the activation of immune cells and on survival against Spring Viremia Carp Virus (SVCV). (A) Zebrafish larvae overexpressing ifng1-2 show the activation of macrophages and neutrophils, with an evident change in morphology from a spherical morphology to a dendritic morphology. (B) Kaplan–Meier survival curves after SVCV challenge in zebrafish larvae overexpressing or not overexpressing ifng1-2 (C) Kaplan–Meier survival curves after SVCV challenge in adult zebrafish co-inoculated or not co-inoculated with the Ifng1-2 recombinant protein. Significant differences are represented by asterisks (*p < 0.05).