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. 2018 Jul 9;9:1575. doi: 10.3389/fimmu.2018.01575

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Copyright © 2018 Álvarez-Rodríguez, Pereiro, Reyes-López, Tort, Figueras and Novoa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of the kynurenine pathway of tryptophan catabolism in zebrafish inoculated with β-glucans. (A) Schematic representation of the kynurenine pathway and the DEGs in the comparison Glucans-Spring Viremia Carp Virus (SVCV) vs. Glucans-PBS (tdo2a, kyat2) and the comparison Glucans-SVCV vs. PBS (tph2). (B) Heatmap representing some of the most affected genes after β-glucan treatment. Whereas ifng1-2 and tdo2a are highly expressed in the Glucans-SVCV group, tph2 and kyat2 have lower expression levels in these fish. A color gradient scheme representing gene modulation (red: lower expression; green: higher expression) is shown on the bottom. (C) Kaplan–Meier survival curves representing the effect of a TDO-inhibitor (C80C91) and an IDO-inhibitor (1-MT) during a challenge with SVCV in adult zebrafish. A significant increase in the survival rate was observed in individuals inoculated with the inhibitors. Significant differences are represented by asterisks (*p < 0.05).