Fig. 3.

Spatial memory assessment. Relative time spent in the new location of the object relocated (% of total object exploration time) throughout the first 12 weeks following surgery. Treatment groups: ovariectomized animals receiving vehicle solution (OVX) (N = 10), sham operated animals (N = 10), and naïve animals (N = 8). Dashed line indicates chance performance of task, which is the same amount of time spent exploring the old and novel object. ANOVA followed by Bonferroni test: *P < 0.05 vs. sham group; ^#P < 0.05 vs. naive group. Data are mean ± SEM