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. 2018 Jul 16;51:22. doi: 10.1186/s40659-018-0169-4

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Intracellular structure changes and generation of reactive oxygen species induced by high glucose. The transmission electron microscopy (a) and flow cytometry analysis (b) of ARPE-19 cells treated with normal glucose (5.5 mM; Control; ×12,000) or high glucose (30 mM; HG; ×30,000) for 48 h. The autophagosomes in ARPE-19 cells were indicated by arrows