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. 2018 Jun 6;9(7):757–760. doi: 10.1021/acsmedchemlett.8b00213

Table 4. Rat Pharmacokinetic Properties of Full Agonistsa.

Compound Fu oral Cmax (μM) oral AUC (μM·h) Cl (L/h/kg) Vdss (L/kg) iv t1/2 (h) % F
8 0.006 0.37 1.74 0.67 1.12 2.1 29
4 0.006 0.25 1.83 0.72 1.68 2.0 34
14 0.003 1.18 8.22 0.33 0.81 2.0 72
18 0.003 0.36 2.43 0.49 1.9 3.3 32
a

Administered at a dose of 0.5 mg/kg, iv; 2 mg/kg, po, in rats. Data are expressed as mean values (n = 3).