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. 2018 Jun 6;9(7):757–760. doi: 10.1021/acsmedchemlett.8b00213

Table 5. Pharmacokinetic Properties of Full Agonist 14a.

Compound Species Fu oral dose (mg/kg) oral AUC (μM·h) Cl (L/h/kg) Vdss (L/kg) iv t1/2 (h) % F
2 rat 0.010 2 15.1 0.91 1.1 1.8 72
14 rat 0.003 2 8.22 0.33 0.81 2.0 72
14 dog 0.034 2 11.6 0.21 0.68 4.1 62
2 cyno 0.012 10 18.8 0.81 2.0 2.1 71
14 cyno 0.017 10 80.4 0.22 0.5 3.3 91
a

Administered at a dose of 0.5 mg/kg, iv. Data are expressed as mean values (n = 3).