Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Intracellular metformin concentration in human HEK cells in different buffers. Time course of intracellular metformin concentrations in HEK-EV (●) and HEK-OCT1 (▪) in (A) low K+, 5.4 mM KCl buffer, and (B) high K+, 140 mM KCl buffer. The ICS of HEK-EV (1.21 µl/106 cells) and HEK-OCT1 (1.25 µl/106 cells) was used to calculate the metformin unbound intracellular concentrations in two different buffers. Data are presented as mean ± S.E.M. *P < 0.05.
