TABLE 1.
Summary of Bmax values for specific [3H]citalopram binding in SERT+/+ and SERT+/− mice
Data are mean ± S.E.M. fmol/mg protein. There was no significant difference between males and females for any age or SERT genotype; therefore, data for both genders were pooled. Tukey’s multiple comparisons test after two-factor ANOVA, n = 8–11.
| Genotype | P21 | P28 | P90 |
|---|---|---|---|
| Prefrontal cortex | |||
| SERT+/+ | 568 ± 25 | 588 ± 25 | 583 ± 18 |
| SERT+/− | 322 ± 32 | 331 ± 15 | 363 ± 28 |
| Parietal cortex | |||
| SERT+/+ | 342 ± 24* | 382 ± 21 | 431 ± 24 |
| SERT+/− | 186 ± 37 | 214 ± 24 | 225 ± 22 |
| Amygdala | |||
| SERT+/+ | 970 ± 31 | 1032 ± 29 | 1058 ± 29 |
| SERT+/− | 669 ± 58 | 678 ± 21a | 801 ± 48 |
| Ventromedial hypothalamus | |||
| SERT+/+ | 999 ± 38 | 933 ± 37 | 938 ± 30 |
| SERT+/− | 696 ± 57 | 677 ± 29 | 597 ± 37 |
a
Difference from SERT genotype–matched P90 group, *P < 0.05.