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Mean TSSC in the (a) morning and (b) evening assessed by subject. For QAM dosing, evening scores are 12 hours postdose and morning scores are 24 hours postdose. For QHS, evening scores are 24 hours postdose and morning scores are 12 hours postdose. *P ≤ .05 versus placebo. BID, twice-daily; QAM, once-daily morning; QHS, once-daily bedtime; TSSC, total symptom severity complex.
