Table 1.

Cell Therapy and Senescence Markers in Kidney Tissue.

Model	Recipients	Cell Treatment	Senescence Markers	Klotho	Ref.
AKI-IRI	Adult rats	WJ-hMSCs	↓ p16 ↓ p21  ↓ TGF-β  ↓ β-galactosidase  ↓ miR-29a ↓ miR-34a	↑	Rodrigues et al.34
Aging	Old mice	Old BMCs	↑ Collagen IV  ↑ PAI-1  ↓ PDGF-B	↓	Yang et al.127
Aging	Old mice	Young BMCs	↓ Collagen IV  ↓ PAI-1  ↑ PDGF-B	↑	Yang et al.127

Abbreviations: AKI, acute kidney injury; IRI, ischemia–reperfusion injury; WJ-hMSCS, Wharton’s jelly-derived human mesenchymal stem cells; BMCs, bone marrow–derived cells; PAI-1, plasminogen activator inhibitor-1; PDGF-B, platelet-derived growth factor subunit B; microRNA, miR.