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. 2018 Apr 30;27(5):831–839. doi: 10.1177/0963689717742662

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Fig. 2. — Expression of genes related with detoxification enzymes in the olfactory bulb. (A) RT-PCR analysis of 6 genes related to detoxification enzymes in the OB of PD mice at 10 mo of age: Cytochrome P450 family 1 subfamily A member 2 (CYP1A2), paraoxonase 1 (PON1), alcohol dehydrogenase 1 (ADH1), aldehyde oxidase homolog 2 (AOH2), UDP glucuronosyltransferase family 2 member A1 complex locus (UGT2A1), and aldehyde glutathione peroxidase 6 (GPX6). (B) Quantitative comparison of gene expression in the PD control (N = 5) and PD EE group (N = 5) relative to WT mice (N = 5) at 10 mo of age determined by RT-qPCR. The expression of CYP1A2 (1.59-fold, P < 0.05), PON1 (4.39-fold, P < 0.001), ADH1 (1.43-fold, P < 0.05), AOH2 (2.26-fold, P < 0.01), UGT2A1 (2.55-fold, P < 0.05), and GPX6 (2.50-fold, P < 0.05) was significantly increased in the PD control group compared to the WT group. On the other hand, the expression of CYP1A2 (0.70-fold, P < 0.01), PON1 (1.20-fold, P < 0.001), ADH1 (1.17-fold), AOH2 (0.79-fold, P < 0.01), UGT2A1 (0.79-fold, P < 0.01), and GPX6 (1.10-fold, P < 0.05) was decreased in the PD EE group compared to the PD control group. Abbreviations: RT-PCR = reverse transcription polymerase chain reaction; OB = olfactory bulb; PD = Parkinson's disease; EE = enriched environment; WT = wild type; RT-qPCR = real-time quantitative polymerase chain reaction. *P < 0.05, **P < 0.01, and ***P < 0.001 are based on a one-way analysis of variance followed by a post hoc test.