Extended Data Figure 3. Analysis of CD11c^Cre; BRAF^V600E mouse model.

(a) Kaplan-Meier survival curve of BRAF^VE (n=16) and BRAF^WT (n=66) controls. Log-rank (Mantel-Cox) test. (b) Representative photographs of lung and spleen from BRAF^VE mice at time of death with representative BRAF^WT control organs. (c–d) Hematoxylin and eosin (HE) stain of lung tissue from BRAF^VE and littermate controls. (e) CD68 immunohistochemistry (IHC) of BRAF^VE lung tissue. (f) HE stain of liver tissue from BRAF^VE and littermate controls with magnified view of granuloma in the BRAF^VE liver. (g) HE stain of bone marrow (BM) from BRAF^VE and littermate controls with CD68 IHC of BRAF^VE mouse. All pictures for (b-g) are representative of n=5 per genotype.