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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Tetrahedron Lett. 2017 Oct 23;58(48):4525–4531. doi: 10.1016/j.tetlet.2017.10.041

Table 1.

CuTC promoted coupling of 4-substituted 2-N-methylpiperazine-5-iodopyrimidines with arylthiols.

graphic file with name nihms917254u2.jpg
entry R HS-Ar product % yield
5 OMe graphic file with name nihms917254t1.jpg graphic file with name nihms917254t2.jpg 74a
6 OMe graphic file with name nihms917254t3.jpg graphic file with name nihms917254t4.jpg 76
7 OMe graphic file with name nihms917254t5.jpg graphic file with name nihms917254t6.jpg 68
8 OMe graphic file with name nihms917254t7.jpg graphic file with name nihms917254t8.jpg 73
9 OBn graphic file with name nihms917254t9.jpg graphic file with name nihms917254t10.jpg 79
10 OBn graphic file with name nihms917254t11.jpg graphic file with name nihms917254t12.jpg 75
11 OBn graphic file with name nihms917254t13.jpg graphic file with name nihms917254t14.jpg 82
12 OBn graphic file with name nihms917254t15.jpg graphic file with name nihms917254t16.jpg 76
13 OBn graphic file with name nihms917254t17.jpg graphic file with name nihms917254t18.jpg 78
14 OBn graphic file with name nihms917254t19.jpg graphic file with name nihms917254t20.jpg 82
15 OBn graphic file with name nihms917254t21.jpg graphic file with name nihms917254t22.jpg 92
16 OBn graphic file with name nihms917254t23.jpg graphic file with name nihms917254t24.jpg 64
17 OBn graphic file with name nihms917254t25.jpg graphic file with name nihms917254t26.jpg 76
a

0.3 eq. CuTC used.