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. Author manuscript; available in PMC: 2018 Nov 29.
Published in final edited form as: Tetrahedron Lett. 2017 Oct 23;58(48):4525–4531. doi: 10.1016/j.tetlet.2017.10.041

Table 5.

CuTC promoted coupling of 4-benzyl 2-N-methylpiperazine-5-iodopyridine or -phenyl with arylthiols.

graphic file with name nihms917254u6.jpg
entry X1, X2 HS-Ar product % yield
28 N, C graphic file with name nihms917254t44.jpg graphic file with name nihms917254t45.jpg 85
29 N, C graphic file with name nihms917254t46.jpg graphic file with name nihms917254t47.jpg 74
30 N, C graphic file with name nihms917254t48.jpg graphic file with name nihms917254t49.jpg 77
31 C, N graphic file with name nihms917254t50.jpg graphic file with name nihms917254t51.jpg 82
32 C, C graphic file with name nihms917254t52.jpg graphic file with name nihms917254t53.jpg 82
33 C, C graphic file with name nihms917254t54.jpg graphic file with name nihms917254t55.jpg 47