Table 4.
Variable | MV, YFV, MenAV, and PRV | MV, YFV, and MenAV | Difference, Percentage Points | P | ||
---|---|---|---|---|---|---|
Proportion | Percentage (95% CI) | Proportion | Percentage (95% CI) | |||
Level | ||||||
IgA | ||||||
≥3-fold increase from baseline to day 28 | 131/292 | 44.9 (39.2–50.6) | 80/292 | 27.4 (22.3–32.5) | 17.5 | <.0001 |
≥20 U/mL | ||||||
Overall | 218/292 | 74.7 (69.7–79.6) | 172/292 | 58.9 (53.3–64.5) | 15.8 | <.0001 |
Baseline level <20 U/mL | 91/160 | 56.9 (49.2–64.5) | 52/165 | 31.5 (24.4–38.6) | 25.4 | <.0001 |
IgM | ||||||
≥3-fold increase from baseline to day 28 | 168/293 | 57.3 (51.7–63.0) | 77/293 | 26.3 (21.2–31.3) | 31.1 | <.0001 |
≥20 U/mL | ||||||
Overall | 275/293 | 93.9 (91.1–96.6) | 223/293 | 76.1 (71.2–81.0) | 17.7 | <.0001 |
Baseline level <20 U/mL | 76/91 | 83.5 (75.9–91.1) | 29/92 | 31.5 (22.0–41.0) | 52.0 | <.0001 |
Time point | GMC (95% CI) | GMC (95% CI) | GMC Ratio | |||
IgA | ||||||
Baseline | 25.3 (19.7–32.6) | 23.7 (18.6–30.3) | … | |||
Day 28 | 118.4 (90.9–154.3) | 67.9 (49.9–92.3) | 1.7 | .0033 | ||
IgG | ||||||
Baseline | 62.5 (49.6–78.8) | 58.9 (47.1–73.7) | … | |||
Day 28 | 363.6 (293.6–450.4) | 153.3 (113.8–206.5) | 2.3 | <.0001 |
Abbreviations: CI, confidence interval; GMC, geometric mean concentration; MenAV, meningococcal A conjugate vaccine; MV, measles vaccine; PRV, pentavalent rotavirus vaccine; YFV, yellow fever vaccine.