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. 2018 Apr 12;218(4):606–613. doi: 10.1093/infdis/jiy215

Table 4.

Anti–Rotavirus Immunoglobulin A (IgA) and Immunoglobulin G (IgG) Responses in Infants, by Vaccines Received—Per-Protocol Population

Variable MV, YFV, MenAV, and PRV MV, YFV, and MenAV Difference, Percentage Points P
Proportion Percentage (95% CI) Proportion Percentage (95% CI)
Level
 IgA
  ≥3-fold increase from baseline to day 28 131/292 44.9 (39.2–50.6) 80/292 27.4 (22.3–32.5) 17.5 <.0001
  ≥20 U/mL
   Overall 218/292 74.7 (69.7–79.6) 172/292 58.9 (53.3–64.5) 15.8 <.0001
   Baseline level <20 U/mL 91/160 56.9 (49.2–64.5) 52/165 31.5 (24.4–38.6) 25.4 <.0001
 IgM
  ≥3-fold increase from baseline to day 28 168/293 57.3 (51.7–63.0) 77/293 26.3 (21.2–31.3) 31.1 <.0001
  ≥20 U/mL
   Overall 275/293 93.9 (91.1–96.6) 223/293 76.1 (71.2–81.0) 17.7 <.0001
   Baseline level <20 U/mL 76/91 83.5 (75.9–91.1) 29/92 31.5 (22.0–41.0) 52.0 <.0001
Time point GMC (95% CI) GMC (95% CI) GMC Ratio
 IgA
  Baseline 25.3 (19.7–32.6) 23.7 (18.6–30.3)
  Day 28 118.4 (90.9–154.3) 67.9 (49.9–92.3) 1.7 .0033
 IgG
  Baseline 62.5 (49.6–78.8) 58.9 (47.1–73.7)
  Day 28 363.6 (293.6–450.4) 153.3 (113.8–206.5) 2.3 <.0001

Abbreviations: CI, confidence interval; GMC, geometric mean concentration; MenAV, meningococcal A conjugate vaccine; MV, measles vaccine; PRV, pentavalent rotavirus vaccine; YFV, yellow fever vaccine.