Table 5.
Meningococcus Serotype A Serum Bactericidal Responses in Infants, by Vaccines Received, Per-Protocol Population
| Variable | MV, YFV, MenAV, and PRV | MV, YFV, and MenAV | Difference, Percentage Points (95% CI) | ||
|---|---|---|---|---|---|
| Proportion | Percentage (95% CI) | Proportion | Percentage (95% CI) | ||
| Serologic finding | |||||
| Seroresponsea | 273/292 | 93.5 (90.7–96.3) | 276/293 | 94.2 (91.5–96.9) | −0.7 (−5.2–3.8) |
| Bactericidal titer | |||||
| ≥8 | 282/292 | 96.6 (94.5–98.7) | 282/293 | 96.2 (94.1–98.4) | 0.3 (−3.8–4.4) |
| ≥128 | 276/292 | 94.5 (91.9–97.1) | 276/292 | 94.2 (91.5–96.9) | 0.3 (−4.1–4.8) |
| Time point | GMT (95% CI) | GMT (95% CI) | GMT Ratio (95% CI) | ||
| Baseline | 3.22 (2.68–3.88) | 2.81 (2.40–3.28) | … | ||
| Day 28 | 2014.25 (1626.21–2494.89) | 2097.03 (1693.18–2597.20) | 0.94b (.69–1.26) | ||
Abbreviations: CI, confidence interval; GMT, geometric mean titer; MenAV, meningococcal A conjugate vaccine; MV, measles vaccine; PRV, pentavalent rotavirus vaccine; YFV, yellow fever vaccine
aDefined as a ≥4-fold increase in titer from baseline to day 28.
b P = .6709.