Table 1.
Antigens Used in Various Assays
| IAV Strain | Abbreviation | IAV Subtype | Clade | Pathogenicity | Assay(s)a |
|---|---|---|---|---|---|
| A/NewCaledonia/20/1999 | sH1N1 | H1N1 | … | Seasonal | PA |
| A/Wyoming/3/03 | sH3N2 | H3N2 | … | Seasonal | PA |
| A/duck/Hokkaido/167/07 | H5N3/07 | H5N3 | … | LPAI | PA |
| A/duck/NY/191255–59/02 | H5N8/02 | H5N8 | … | LPAI | PA |
| A/HongKong/156/97 | HK/97 | H5N1 | 0 | HPAI | PA |
| A/Vietnam/1194/04 | VN/04 | H5N1 | 1 | HPAI | PA, HI, VN, ADCC, T cell |
| A/Cambodia/R0405050/07 | CAM/07 | H5N1 | 1.1 | HPAI | PA |
| A/Indonesia/5/05 | IND/05 | H5N1 | 2.1 | HPAI | PA, HI, VN, ADCC, T cell |
| A/duck/Hunan/795/02 | HUN/02 | H5N1 | 2.1.3.2 | HPAI | PA |
| A/Turkey/15/06 | TUR/06 | H5N1 | 2.2 | HPAI | PA |
| A/Egypt/N03072/10 | Egypt/10 | H5N1 | 2.2.1 | HPAI | PA |
| A/chicken/Egypt/0879-NLQP/08 | Egypt/08 | H5N1 | 2.2.1.1 | HPAI | PA |
| A/Egypt/N01753/14 | Egypt/14 | H5N1 | 2.2.1.2 | HPAI | HI and VN |
| A/Hubei/1/10 | Hubei/10 | H5N1 | 2.3.2.1 | HPAI | PA |
| A/duck/Bangladesh/19097/13 | BANG/13 | H5N1 | 2.3.2.1 | HPAI | HI and VN |
| A/Anhui/1/05 | Anhui/05 | H5N1 | 2.3.4 | HPAI | PA |
| A/Vietnam/HN31432M/08 | VN/08 | H5N1 | 2.3.4.2 | HPAI | PA |
| A/turkey/Germany-MV/R2472/14 | tu/H5N8/14 | H5N8 | 2.3.4.4 | HPAI | PA |
| A/Guangzhou/39715/14 | H5N6/14 | H5N6 | 2.3.4.4 | HPAI | HI and VN |
| A/chicken/Netherlands/EMC-3/14 | ch/H5N8/14 | H5N8 | 2.3.4.4 | HPAI | HI and VN |
| A/chicken/Yamaguchi/7/04 | YAM/04 | H5N1 | 2.5 | HPAI | PA |
| A/goose/Guiyang/337/06 | GUI/06 | H5N1 | 4 | HPAI | PA |
| A/chicken/Vietnam/NCVD-016/08 | ch/VN/08 | H5N1 | 7 | HPAI | PA |
| A/chicken/Jilin/9/04 | JI/04 | H5N1 | … | HPAI | PA |
Abbreviations: ADCC, antibody-dependent cellular cytotoxicity; HI, hemagglutination inhibition; HPAI, high-pathogenicity avian influenza virus; IAV, influenza A virus; LPAI, low-pathogenicity avian influenza virus; PA, protein array; VN, virus neutralization.
aHemagglutinin subunit 1 (HA1) was used in PA analysis, viruses created using reverse-genetics techniques were used for HI/VN assays, and full-length HA was used for ADCC and T-cell assays.