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. 2018 Jul 12;13:4093–4105. doi: 10.2147/IJN.S145837

Figure 6.

Figure 6

Pathological analysis of colon tissues after distinct treatments using H&E staining assay, magnification =100×. (A) Normal control, (B) CA/BaSO4 microcapsule treatment, (C) DSS induction, (D) sulfasalazine treatment after DSS induction, (E) 0.6×109 Bifidobacterium-loading CA/BaSO4 microcapsule treatment after DSS induction, (F) 1.2×109 Bifidobacterium by microcapsule treatment after DSS induction, (G) 2.4×109 Bifidobacterium by microcapsule treatment after DSS induction, (H) 2.4×109 Bifidobacterium treatment after DSS induction. The blue circles denote infiltration of mononuclear, submucosal lymphoid hyperplasia, and extension around intestinal glands; yellow arrows denote the distortion of crypts and loss of goblet cells; the green arrows denote the severe mucosal damage in the colon.

Abbreviations: CA/BaSO4, chitosan-coated alginate microcapsule loaded with in situ synthesized barium sulfate; DSS, dextran sulfate sodium.