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. 2018 Jul 13;12:2195–2211. doi: 10.2147/DDDT.S167405

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© 2018 Tian et al. This work is published and licensed by Dove Medical Press Limited

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Effect of emodin on nephrin and GRP78 expression of kidney in KK-Ay mice. (A–D) The protein levels and quantification of nephrin and GRP78 in the mice renal cortexes were detected by Western blot, nephrin, or GRP78 expression was normalized to β-actin expression. (E, F) Representative immunohistochemical staining and quantification of nephrin expression in KK-Ay mice. Brownish or yellowish deposits were regarded as positive immunostaining (original magnification ×400, n=4). (G) The mRNA levels of GRP78 in the mice renal cortexes were detected by RT-PCR. The results were normalized to the normal group, and data are shown as the mean±SD; n=3. #P<0.001 versus the normal group; *P<0.05 and **P<0.001 versus the model group.

Abbreviation: GRP78, 78 kDa glucose-regulated protein.