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. 2018 Jul 13;12:2195–2211. doi: 10.2147/DDDT.S167405

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© 2018 Tian et al. This work is published and licensed by Dove Medical Press Limited

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The induction of ER stress marker GRP78 was attenuated by emodin in podocytes. (A, B) The protein levels and quantification of GRP78 in podocytes were detected by Western blot. (C, D) Representative immunofluorescent staining and quantification of the fluorescence intensity of GRP78. In all histograms, the results were normalized to the normal group, and the data are shown as the mean±SD; n=3. ^#P<0.001 versus the normal group; *P<0.05 and **P<0.001 versus the model group. ^ΔP<0.05 versus TM group.

Abbreviations: ER, endoplasmic reticulum; GRP78, 78 kDa glucose-regulated protein; TM, tunicamycin; HG, high glucose; TUDCA, tauroursodeoxycholic acid; DAPI, 4′,6-diamidino-2-phenylindole.