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. 2018 Jul 12;13:4107–4119. doi: 10.2147/IJN.S163929

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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(A) Intracellular ATP level in MCF-7 ADR cells after 4 h incubation with different formulations. (B) Effects of different formulations on P-gp expression in MCF-7 ADR cells, as determined by Western blot analysis. Tubulin was used as a loading control. (C) Quantitative analysis of Western blot assay. **P < 0.01. Data were shown as mean ± SD (n = 3).

Abbreviations: DNLC, DOX mono-delivery NLC; LNLC, Lapa mono-delivery NLC; LDNLC, NLC co-delivering Lapa and DOX; DOX, doxorubicin; NLC, nanostructured lipid carrier; Lapa, β-lapachone; Di, dicoumarol.