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. 2018 Jul 12;13:4107–4119. doi: 10.2147/IJN.S163929

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© 2018 Li et al. This work is published and licensed by Dove Medical Press Limited

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(A) In vivo imaging of biodistribution of MCF-7 ADR tumor xenograft mice after injection of free DiR or DiR-loaded LDNLC. (B) DOX concentration in blood as a function of time after a single intravenous administration of free DOX or LDNLC. (C) Distribution profiles of total DOX in tissues at 24 h after a single intravenous administration of free DOX or LDNLC. Data were shown as mean ± SD (n = 3).

Abbreviations: LDNLC, NLC co-delivering Lapa and DOX; DOX, doxorubicin; NLC, nanostructured lipid carrier; Lapa, β-lapachone; DiR,.