Skip to main content
. 2018 Jul 12;10:371–387. doi: 10.2147/CEOR.S162964

Table S3.

Patient, visit, and hospital characteristics by antifungal use

AML Single antifungal (posaconazole) Single antifungal (not posaconazole) Multiple antifungals (including posaconazole) Multiple antifungals (not including posaconazole) No antifungal
Unique patients 565 4,778 812 2,235 11,482
Unique providers 103 516 112 309 724
Age, years Minimum– 0 85+ 0 85+ 5 85+ 0 85+ 0 85+
maximum
Mean 57 58 56 54 69
SD ±16.35 ±19.88 ±15.52 ±18.33 ±17.72
Median 60 63 59 58 73
IQR 47 69 48 73 45 68 44 67 61 81
Age-group, years 0–17 9 1.6% 246 5.1% 4 0.5% 118 5.3% 185 1.6%
18–34 51 9.0% 397 8.3% 91 11.2% 243 10.9% 535 4.7%
35–44 66 11.7% 373 7.8% 96 11.8% 208 9.3% 510 4.4%
45–64 231 40.9% 1,571 32.9% 353 43.5% 940 42.1% 2,254 19.6%
65–74 134 23.7% 1,189 24.9% 195 24.0% 531 23.8% 2,721 23.7%
75+ 74 13.1% 1,002 21.0% 73 9.0% 195 8.7% 5,277 46.0%
Sex Male 334 59.1% 2,662 55.7% 398 49.0% 1,191 53.3% 6,337 55.2%
Female 231 40.9% 2,115 44.3% 414 51.0% 1,042 46.6% 5,143 44.8%
Unknown 0 0 1 0 0 0 2 0.1% 2 0
Race White 398 70.4% 3,327 69.6% 600 73.9% 1,517 67.9% 8,367 72.9%
Black 46 8.1% 469 9.8% 77 9.5% 237 10.6% 1,088 9.5%
Other 121 21.4% 982 20.6% 135 16.6% 481 21.5% 2,027 17.7%
Ethnicity Not Hispanic or Latino 310 54.9% 2,139 44.8% 459 56.5% 1,036 46.4% 5,379 46.8%
Hispanic or Latino 52 9.2% 348 7.3% 56 6.9% 159 7.1% 619 5.4%
Other 203 35.9% 2,291 47.9% 297 36.6% 1,040 46.5% 5,484 47.8%
Admission type Urgent/emergent 464 82.1% 3,896 81.5% 639 78.7% 1,840 82.3% 9,926 86.4%
Elective 91 16.1% 847 17.7% 151 18.6% 375 16.8% 1,449 12.6%
Trauma 0 0 13 0.3% 1 0.1% 8 0.4% 30 0.3%
Other/unknown 10 1.8% 22 0.5% 21 2.6% 12 0.5% 77 0.7%
Discharge status Home 440 77.9% 3,093 64.7% 592 72.9% 1,480 66.2% 4,606 40.1%
Transferred 19 3.4% 356 7.5% 28 3.4% 105 4.7% 1,979 17.2%
SNF 15 2.7% 166 3.5% 27 3.3% 75 3.4% 594 5.2%
Expired 51 9.0% 691 14.5% 119 14.7% 412 18.4% 1,961 17.1%
Hospice 31 5.5% 393 8.2% 33 4.1% 138 6.2% 2,025 17.6%
Other/unknown 9 1.6% 79 1.7% 13 1.6% 25 1.1% 317 2.8%
No. of beds 1–149 2 0.4% 140 2.9% 1 0.1% 29 1.3% 885 7.7%
150–249 7 1.2% 492 10.3% 37 4.6% 229 10.2% 1,601 13.9%
250–349 60 10.6% 625 13.1% 104 12.8% 220 9.8% 1,960 17.1%
350–449 119 21.1% 661 13.8% 134 16.5% 255 11.4% 2,203 19.2%
450–549 34 6.0% 738 15.4% 36 4.4% 324 14.5% 1,615 14.1%
550+ 343 60.7% 2,122 44.4% 500 61.6% 1,178 52.7% 3,218 28.0%
Geographic region West 44 7.7% 807 16.9% 53 6.5% 338 15.1% 2,046 17.8%
Midwest 55 9.8% 737 15.5% 87 10.7% 372 16.7% 2,330 20.3%
Northeast 183 32.4% 817 17.1% 196 24.1% 405 18.2% 2,115 18.4%
South 283 50.1% 2417 50.7% 476 58.7% 1120 50.2% 4,991 43.5%
Teaching Yes 156 27.6% 2,133 44.6% 187 23.0% 819 36.6% 6,110 53.2%
No 409 72.4% 2,645 55.4% 625 77.0% 1,416 63.4% 5,372 46.8%
Urban/rural Rural 6 1.1% 244 5.1% 11 1.4% 82 3.7% 1,007 8.8%
Urban 559 98.9% 4,534 94.9% 801 98.6% 2,153 96.3% 10,475 91.2%
MDS
Unique patients 29 624 17 73 11,382
Unique providers 19 300 10 56 748
Age, years Minimum–maximum 20 85 0 85+ 6 81 1 85+ 0 85+
Mean 62 68 57 65 77
SD ±15.31 ±14.99 ±19.28 ±13.64 ±12.36
Median 68 71 62 66 79
IQR 53 73 61 79 51 68 58 73 71 86
Age-group, years 0–17 0 0 5 0.8% 1 5.9% 1 1.4% 39 0.3%
18–34 2 6.9% 22 3.5% 1 5.9% 1 1.4% 63 0.6%
35–44 2 6.9% 13 2.1% 0 0 2 2.7% 101 0.9%
45–64 8 27.6% 162 26.0% 9 52.9% 29 39.7% 1,368 12.0%
65–74 13 44.8% 172 27.6% 3 17.6% 23 31.5% 2,431 21.4%
75+ 4 13.8% 250 40.1% 3 17.6% 17 23.3% 7,380 64.8%
Sex Male 21 72.4% 377 60.4% 7 41.2% 36 49.3% 6,187 54.4%
Female 8 27.6% 246 39.4% 10 58.8% 37 50.7% 5,194 45.6%
Unknown 0 0 1 0.2% 0 0 0 0 1 0
Race White 18 62.1% 453 72.6% 12 70.6% 54 74.0% 8,401 73.8%
Black 5 17.2% 57 9.1% 2 11.8% 7 9.6% 1,050 9.2%
Other 6 20.7% 114 18.3% 3 17.6% 12 16.4% 1,931 17.0%
Ethnicity Not Hispanic or 17 58.6% 295 47.3% 11 64.7% 41 56.2% 5,441 47.8%
Latino
Hispanic or Latino 3 10.3% 44 7.1% 1 5.9% 2 2.7% 612 5.4%
Other 9 31.0% 285 45.7% 5 29.4% 30 41.1% 5,329 46.8%
Admission type Urgent/emergent 18 62.1% 510 81.7% 13 76.5% 58 79.4% 9,857 86.6%
Elective 11 37.9% 109 17.5% 4 23.5% 14 19.2% 1,434 12.6%
Trauma 0 0 1 0.2% 0 0 1 1.4% 21 0.2%
Other/unknown 0 0 4 0.6% 0 0 0 0 70 0.6%
Discharge status Home 25 86.2% 399 63.9% 14 82.4% 28 38.4% 7,775 68.3%
Transferred 0 0 25 4.0% 1 5.9% 8 11.0% 301 2.6%
SNF 0 0 70 11.2% 1 5.9% 8 11.0% 1,996 17.5%
Expired 2 6.9% 64 10.3% 0 0 18 24.7% 457 4.0%
Hospice 1 3.4% 57 9.1% 1 5.9% 11 15.1% 744 6.5%
Other/unknown 1 3.4% 9 1.4% 0 0 0 0 109 1.0%
No. of beds 1–149 0 0 32 5.1% 0 0 2 2.7% 1,053 9.3%
150–249 1 3.4% 85 13.6% 1 5.9% 9 12.3% 1,846 16.2%
250–349 4 13.8% 112 17.9% 1 5.9% 8 11.0% 2,187 19.2%
350–449 4 13.8% 99 15.9% 3 17.6% 10 13.7% 2,097 18.4%
450–549 1 3.4% 103 16.5% 1 5.9% 16 21.9% 1,564 13.7%
550+ 19 65.5% 193 30.9% 11 64.7% 28 38.4% 2,635 23.2%
Geographic region West 3 10.3% 94 15.1% 1 5.9% 10 13.7% 1,813 15.9%
Midwest 2 6.9% 75 12.0% 2 11.8% 9 12.3% 2,192 19.3%
Northeast 10 34.5% 110 17.6% 4 23.5% 12 16.4% 2,289 20.1%
South 14 48.2% 345 55.3% 10 58.9% 42 57.6% 5,088 44.7%
Teaching Yes 9 31.0% 338 54.2% 3 17.6% 30 41.1% 6,557 57.6%
No 20 69.0% 286 45.8% 14 82.4% 43 58.9% 4,825 42.4%
Urban/rural Rural 0 0 48 7.7% 0 0 6 8.2% 1,039 9.1%
Urban 29 100% 576 92.3% 17 100% 67 91.8% 10,343 90.9%
HSCT
Unique patients 109 7,513 228 1,634 4,736
Unique providers 31 175 35 71 382
Age, years Minimum–maximum 1 85+ 0 85+ 4 82 0 85 0 85+
Mean 53 53 52 43 51
SD ±16.48 ±17.52 ±15.63 ±22.28 ±22.48
Median 57 58 55 51 57
IQR 46 64 46 65 44.5 63 24 61 38 67
Age-group, years 0–17 4 3.7% 470 6.3% 8 3.5% 326 20 687 14.5%
18–34 13 11.9% 617 8.2% 28 12.3% 194 11.9% 404 8.5%
35–44 8 7.3% 622 8.3% 21 9.2% 153 9.4% 329 6.9%
45–64 59 54.1% 3,711 49.4% 121 53.1% 674 41.2% 1,864 39.4%
65–74 19 17.4% 1,914 25.5% 46 20.2% 269 16.5% 985 20.8%
75 + 6 5.5% 179 2.4% 4 1.8% 18 1.1% 467 9.9%
Sex Male 63 57.8% 4,345 57.8% 138 60.5% 955 58.4% 2,604 55.0%
Female 46 42.2% 3,168 42.2% 90 39.5% 679 41.6% 2,132 45.0%
Unknown 0 0 0 0 0 0 0 0 0 0
Race White 69 63.3% 5,359 71.3% 138 60.5% 1,034 63.3% 3,430 72.4%
Black 6 5.5% 873 11.6% 18 7.9% 196 12.0% 539 11.4%
Other 34 31.2% 1,281 17.1% 72 31.6% 404 24.7% 767 16.2%
Ethnicity Not Hispanic or Latino 70 64.2% 4,354 58.0% 118 51.8% 819 50.1% 3,288 69.4%
Hispanic or Latino 10 9.2% 482 6.4% 14 6.1% 111 6.8% 350 7.4%
Other 29 26.6% 2,677 35.6% 96 42.1% 704 43.1% 1,098 23.2%
Admission type Urgent/emergent 43 39.5% 2,352 31.3% 82 35.9% 508 31.1% 2,158 45.5%
Elective 65 59.6% 5,117 68.1% 146 64.0% 1,113 68.1% 2,551 53.9%
Trauma 0 0 2 0 0 0 1 0.1% 1 0
Other/unknown 1 0.9% 42 0.6% 0 0 12 0.7% 26 0.5%
Discharge status Home 107 98.2% 7,197 95.8% 194 85.1% 1,388 84.9% 4,298 90.8%
Transferred 1 0.9% 53 0.7% 4 1.8% 32 2.0% 67 1.4%
SNF 0 0 92 1.2% 0 0 27 1.7% 203 4.3%
Expired 1 0.9% 62 0.8% 25 11.0% 150 9.2% 80 1.7%
Hospice 0 0 17 0.2% 2 0.9% 14 0.9% 58 1.2%
Other/unknown 0 0 92 1.2% 3 1.3% 23 1.4% 30 0.6%
No. of beds 1–149 0 0 12 0.2% 0 0 0 0 90 1.9%
150–249 4 3.7% 833 11.1% 8 3.5% 202 12.4% 530 11.2%
250–349 4 3.7% 421 5.6% 9 3.9% 65 4.0% 460 9.7%
350–449 24 22.0% 477 6.3% 26 11.4% 69 4.2% 703 14.8%
450–549 5 4.6% 531 7.1% 8 3.5% 134 8.2% 767 16.2%
550+ 72 66.1% 5,239 69.7% 177 77.6% 1,164 71.2% 2,186 46.2%
Geographic region West 10 9.2% 687 9.1% 9 3.9% 70 4.3% 767 16.2%
Midwest 15 13.7% 1116 14.8% 24 10.5% 271 16.6% 971 20.5%
Northeast 31 28.4% 2,740 36.5% 93 40.8% 630 38.6% 855 18.0%
South 53 48.7% 2970 39.5% 102 44.7% 663 40.6% 2,143 45.3%
Teaching Yes 28 25.7% 1,606 21.4% 24 10.5% 243 14.9% 1,832 38.7%
No 81 74.3% 5,907 78.6% 204 89.5% 1,391 85.1% 2,904 61.3%
Urban/rural Rural 0 0 143 1.9% 0 0 6 0.4% 247 5.2%
Urban 109 100.0% 7,370 98.1% 228 100.0% 1,628 99.6% 4,489 94.8%
GVHD
Unique patients 225 2,192 231 769 2,014
Unique providers 69 341 37 102 495
Age, years Minimum–maximum 0 74 0 85 12 78 0 77 0 85+
Mean 51 47 50 42 49
SD ±14.53 ±18.86 ±15.13 ±21.12 ±17.92
Median Age-group, years 55 52 53 48 53
IQR 42 62 36 61 42 62 24 59 37 62
Age-group, years 0–17 3 1.3% 230 10.5% 6 2.6% 143 18.6% 143 7.1%
18–34 39 17.3% 289 13.2% 38 16.5% 124 16.1% 297 14.7%
35–44 26 11.6% 250 11.4% 21 9.1% 84 10.9% 245 12.2%
45–64 120 53.3% 1,085 49.5% 125 54.1% 320 41.6% 977 48.5%
65–74 37 16.4% 323 14.7% 40 17.3% 95 12.4% 298 14.8%
75+ 0 0 15 0.7% 1 0.4% 3 0.4% 54 2.7%
Sex Male 144 64.0% 1,268 57.8% 132 57.1% 451 58.6% 1,144 56.8%
Female 81 36.0% 924 42.2% 99 42.9% 318 41.4% 870 43.2%
Unknown 0 0 0 0 0 0 0 0 0 0
Race White 181 80.4% 1,668 76.1% 156 67.5% 554 72.0% 1,455 72.2%
Black 14 6.2% 146 6.7% 23 10.0% 73 9.5% 202 10.0%
Other 30 13.3% 378 17.2% 52 22.5% 142 18.5% 357 17.7%
Ethnicity Not Hispanic or Latino 157 69.8% 1,295 59.1% 148 64.1% 449 58.4% 1,147 57.0%
Hispanic or Latino 17 7.6% 126 5.7% 11 4.8% 57 7.4% 119 5.9%
Other 51 22.7% 771 35.2% 72 31.2% 263 34.2% 748 37.1%
Admission type Urgent/emergent 179 79.6% 1,576 71.9% 140 60.6% 409 53.1% 1,596 79.2%
Elective 45 20.0% 593 27.1% 89 38.5% 351 45.6% 382 19.0%
Trauma 1 0.4% 5 0.2% 0 0 1 0.1% 8 0.4%
Other/unknown 0 0 18 0.8% 2 0.9% 8 1.0% 28 1.4%
Discharge status Home 186 82.7% 1,702 77.6% 160 69.3% 526 68.4% 1,518 75.4%
Transferred 13 5.8% 201 9.2% 16 6.9% 53 6.9% 199 9.9%
SNF 9 4.0% 55 2.5% 6 2.6% 16 2.1% 106 5.3%
Expired 7 3.1% 130 5.9% 34 14.7% 145 18.9% 89 4.4%
Hospice 3 1.3% 39 1.8% 9 3.9% 14 1.8% 30 1.5%
Other/unknown 7 3.1% 65 3.0% 6 2.6% 15 2.0% 72 3.6%
No. of beds 1–149 2 0.9% 57 2.6% 1 0.4% 4 0.5% 159 7.9%
150–249 10 4.4% 271 12.4% 9 3.9% 150 19.5% 239 11.9%
250–349 12 5.3% 218 9.9% 12 5.2% 31 4.0% 331 16.4%
350–449 19 8.4% 226 10.3% 9 3.9% 44 5.7% 352 17.5%
450–549 20 8.9% 165 7.5% 9 3.9% 40 5.2% 247 12.3%
550+ 162 72.0% 1,255 57.3% 191 82.7% 500 65.0% 686 34.1%
Geographic region West 26 11.5% 271 12.3% 7 3.0% 42 5.5% 432 21.4%
Midwest 24 10.6% 327 14.9% 12 5.2% 114 14.9% 358 17.8%
Northeast 94 41.8% 574 26.2% 118 51.1% 268 34.8% 382 19.0%
South 81 36.0% 1020 46.5% 94 40.7% 345 44.9% 842 41.8%
Teaching Yes 42 18.7% 743 33.9% 16 6.9% 203 26.4% 929 46.1%
No 183 81.3% 1,449 66.1% 215 93.1% 566 73.6% 1,085 53.9%
Urban/rural Rural 3 1.3% 76 3.5% 0 0 5 0.7% 148 7.3%
Urban 222 98.7% 2,116 96.5% 231 100% 764 99.3% 1,866 92.7%

Note: All values are presented as number and percentages unless otherwise designated.

Abbreviations: AML, acute myeloid leukemia; GVHD, graft-vs-host disease; HSCT, hematopoietic stem-cell transplantation; MDS, myelodysplastic syndrome; SNF, skilled nursing facility.