Table 1.
Clinical and histological features of 288 invasive breast cancers according to molecular subtype
| Total (n = 288) | Molecular subtype |
p-value | |||
|---|---|---|---|---|---|
| HR+ (n = 194) | HER2+ (n = 48) | TNBC (n = 46) | |||
| Age (years) | 0.190 | ||||
| Mean (SD) | 50.8 (10.6) | 50.0 (10.1) | 52.5 (11.1) | 52.4 (11.9) | |
| Median (range) | 49 (22–78) | 48 (22–77) | 52 (30–73) | 52 (30–78) | |
| Clinical manifestation | 0.027 | ||||
| Asymptomatic | 85 (29.5) | 67 (34.5) | 9 (18.8) | 9 (19.6) | |
| Palpable lump | 203 (70.5) | 127 (65.5) | 39 (81.2) | 37 (80.4) | |
| FHx of breast cancer | 0.793 | ||||
| Absent | 272 (94.4) | 184 (94.8) | 45 (93.8) | 43 (93.5) | |
| Present | 16 (5.6) | 10 (5.2) | 3 (6.3) | 3 (6.5) | |
| Histological type | 0.004 | ||||
| Ductal, NOS | 248 (86.1) | 159 (82.0) | 48 (100) | 41 (89.1) | |
| Dctal, special | 18 (6.3) | 14 (7.2) | 0 (0) | 4 (8.7) | |
| Lbular | 22 (7.6) | 21 (10.8) | 0 (0) | 1 (2.2) | |
| Focality | 0.006 | ||||
| Unifocal | 205 (71.2) | 135 (69.6) | 29 (60.4) | 41 (89.1) | |
| Multifocal | 83 (28.8) | 59 (30.4) | 19 (39.6) | 5 (10.9) | |
| Tumour size (cm) | 0.639 | ||||
| Mean (SD) | 2.3 (1.3) | 2.2 (1.3) | 2.2 (1.1) | 2.4 (1.2) | |
| Median (range) | 2.0 (0.1–9.5) | 2.0 (0.1–9.5) | 2.1 (0.2–5.3) | 2.2 (0.4–7.7) | |
| Histological grade | <0.001 | ||||
| 1 or 2 | 138 (47.9) | 127 (65.5) | 5 (10.4) | 6 (13.0) | |
| 3 | 150 (52.1) | 67 (34.5) | 43 (89.6) | 40 (87.0) | |
| Associated DCIS | 0.087 | ||||
| Absent | 57 (19.8) | 42 (21.6) | 4 (8.3) | 11 (23.9) | |
| Present | 231 (80.2) | 152 (78.4) | 44 (91.7) | 35 (76.1) | |
| Lymphovascular invasion | 0.002 | ||||
| Absent | 207 (71.9) | 144 (74.2) | 25 (52.1) | 38 (82.6) | |
| Present | 81 (28.1) | 50 (25.8) | 23 (47.9) | 8 (17.4) | |
| Axillary lymph node metastasis | 0.159 | ||||
| Absent | 203 (70.5) | 136 (70.1) | 30 (62.5) | 37 (80.4) | |
| Present | 85 (29.5) | 58 (29.9) | 18 (37.5) | 9 (19.6) | |
| Ki-67 index | <0.001 | ||||
| Low (<14%) | 236 (81.9) | 183 (94.3) | 31 (64.6) | 22 (47.8) | |
| High (≥14%) | 52 (18.1) | 11 (5.7) | 17 (35.4) | 24 (52.2) |
Note. DCIS, ductal carcinoma in situ; FHx, family history; HER2+, human epidermal growth factor receptor 2; HR+, hormone receptor; NOS, not otherwise specified; SD, standard deviation; TNBC, triple negative breast cancer. Data are numbers of cancers with percentages in parentheses unless otherwise indicated.