Figure 1. Contrast-enhanced CT scans of the lungs and liver.

Images were acquired before treatment with gefitinib (A), 11 days after the onset of gefitinib treatment (B), 7 months after treatment onset, when disease progression was apparent for the liver metastases (C), 1 month after the onset of treatment with osimertinib (D), and after 3 months of treatment with osimertinib, when leptomeningeal metastasis had occurred (E). Arrows indicate primary lung lesion.