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. Author manuscript; available in PMC: 2018 Jul 24.
Published in final edited form as: Nature. 2018 Jan 24;555(7694):107–111. doi: 10.1038/nature25757

Extended Data Figure 8. HNRNPK knockdown in HeLa cells.

Extended Data Figure 8

a, Representative Western blot (top) and qRT-PCR quantification of HNRNPK knockdown (each bar is showing the level in a single experiment). Experiment was repeated twice. b, Changes in nuclear/cytoplasmic ratios of genes with the indicated number of HNRNPK eCLIP peaks following HNRNPK knockdown (DESeq2 analysis of two independent replicates). Otherwise as in Figure 4f. n=91–11,016 genes. c, As in b, separately for mRNA and lncRNAs. n=85–10,077 mRNAs per group, 6-939 lncRNAs per group. d, Changes in nuclear/cytoplasmic ratios of mRNAs and lncRNAs with the indicated number of SIRLOIN elements. Otherwise as in Figure 4f. n=53–11,172 mRNAs per group, 10-891 lncRNAs per group.