Skip to main content
. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2018 May 16;1864(8):2538–2549. doi: 10.1016/j.bbadis.2018.05.008

Fig. 6.

Fig. 6

Molecular mechanism of MUC4/X mediated oncogenic signaling in PC tumorigenesis. Schematic diagram showing the oncogenic role of MUC4/X in PC. Ectopic expression of MUC4/X in PC cells resulted in elevated expression of integrin-β1 and increased adhesion to ECM thereby activating downstream FAK/ERK signaling along with cyclin A2 overexpression. Activation of this signaling cascade results in cell proliferation, adhesion, invasion, and metastasis. When the expression of MUC4/X is induced ectopically along with WT-MUC4, it also exhibited a similar aggressive oncogenic phenotype. Overall, overexpression of MUC4/X leads to enhanced aggressiveness of PC.