Fig 6. Targeting eHRP to the plasma membrane.

(a) Neuroblastoma cells transfected with eHRP targeted to the plasma membrane in the light microscope. In eHRP positive cells many more fine processes can be resolved. (b) Electron micrograph of two neighboring eHRP positive cells. eHRP reaction product is found evenly distributed on the extracellular side of the plasma membrane. Even on the finest filopodia (arrowhead) are labeled. The arrow points to the thin labeled extracellular space between a process and a cell body. Bar = 300 nm.