Fig 7. Schematic integrative model of the RES complex function in splicing.

The loss-function of the RES complex induces a global weak defect in splicing, but a strong retention of a subset of introns with the following features: these introns are short, have a higher GC content and flanked by GC-depleted exons, features associated with intron definition splicing mechanism. This splicing defect leads to a brain-related phenotype.