Table V.
Factors associated with understanding of personal genetic test results among males undergoing multigene testing for suspected inherited prostate cancer
| Discordance between self-reported vs. actual genetic test results | p-value | ||||
|---|---|---|---|---|---|
| No | Yes | ||||
| All | 88 | (100.0) | 13 | (100.0) | |
| Site* | 0.015 | ||||
| Site 1 | 41 | (46.6) | 11 | (84.6) | |
| Site 2 | 47 | (53.4) | 2 | (15.4) | |
| Age, Mean (SD) | 62.6 | (8.5) | 62.5 | (5.9) | 0.941 |
| Age, N (%) | >0.999 | ||||
| 30–49 | 6 | (6.8) | 0 | (0.0) | |
| 50–64 | 43 | (48.9) | 7 | (53.8) | |
| 65–89 | 39 | (44.3) | 6 | (46.2) | |
| Race, N (%) | >0.999 | ||||
| Not answered | 1 | (1.1) | 0 | (0.0) | |
| White | 73 | (83.0) | 11 | (84.6) | |
| Black or African American | 12 | (13.6) | 2 | (15.4) | |
| Asian | 1 | (1.1) | 0 | (0.0) | |
| Multiracial | 1 | (1.1) | 0 | (0.0) | |
| Education, N(%) | 0.617 | ||||
| Not answered | 1 | (1.1) | 0 | (0.0) | |
| Less than high school | 1 | (1.1) | 0 | (0.0) | |
| HS/GED or Vocational/Technical School | 11 | (12.5) | 2 | (15.4) | |
| Some College/Associate’s Degree | 12 | (13.6) | 3 | (23.1) | |
| Bachelor’s Degree or higher | 63 | (71.6) | 8 | (61.5) | |
| Knowledge Score, Mean (SD) | 10.1 | (2.9) | 9.0 | (3.5) | 0.283 |
| Literacy Score, Mean (SD) | 4.3 | (0.7) | 4.3 | (0.7) | 0.895 |
| Numeracy Score, Mean (SD) | 2.4 | (0.8) | 2.4 | (1.0) | 0.985 |
| Prostate Cancer Diagnosis, N (%) | 52 | (59.1) | 6 | (46.2) | 0.388 |
| Age of Diagnosis, Mean (SD) | 60.2 | (6.3) | 6 | (60.2) | 0.988 |
| Age of Diagnosis, N (%) | 0.354 | ||||
| 30–49 | 3 | (5.8) | 1 | (16.7) | |
| 50–64 | 34 | (65.4) | 3 | (50.0) | |
| 65–89 | 15 | (28.8) | 2 | (33.3) | |
| Family history of HCS, N (%) | 41 | (46.6) | 2 | (15.4) | 0.039 |
| Family History (FDRs), N (%) | |||||
| Cancer, any site | 81 | (92.0) | 10 | (76.9) | 0.118 |
| Prostate | 53 | (60.2) | 6 | (46.2) | 0.377 |
| Breast | 27 | (30.7) | 2 | (15.4) | 0.338 |
| Ovarian | 3 | (3.4) | 0 | (0.0) | >0.999 |
| Colon | 12 | (13.6) | 3 | (23.1) | 0.404 |
| Pancreatic | 3 | (3.4) | 0 | (0.0) | >0.999 |
| Family History (any relative), N (%) | |||||
| Cancer, any site | 84 | (95.5) | 11 | (84.6) | 0.171 |
| Prostate | 66 | (75.0) | 7 | (53.8) | 0.180 |
| Breast | 46 | (52.3) | 2 | (15.4) | 0.017 |
| Ovarian | 14 | (15.9) | 0 | (0.0) | 0.205 |
| Colon | 19 | (21.6) | 6 | (46.2) | 0.082 |
| Pancreatic | 7 | (8.0) | 0 | (0.0) | 0.590 |
| Genetic test result of VUS | 18 | (20.5) | 12 | (92.3) | <0.001 |
*
Site 1 provided pretest counseling with a video + handout. Post-test disclosure was in-person for men with a mutation and by phone for men with a variant of uncertain significance or negative results. Site 2 provided pretest counseling and post-test disclosure in-person or by telehealth.