Table 1.
Hematology, blood chemistry and liver function tests in SD-treated and control mice.
| Hematology | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| WBC (K/ul) |
Hb (g/dL) | Hematocrit % |
Platelets (K/uL) |
RBC (M/ul) |
RDW % | MCV (fL) | MCH (pg) | MCHC (g/dL) |
MPV (fL) | |
| Control | 6.4±0.7 | 13.8±0.6 | 37.7±2.7 | 816± 273 | 10.0±0.7 | 17.9±0.2 | 37.6±0.3 | 13.7±0.9 | 36.5±2.2 | 6.6±0.2 |
| Treatment | 13.5±1.7* | 14.3±0.6 | 38.5±2.8 | 809±197 | 10.6±0.7 | 19.4±0.8* | 36.5±0.7 | 13.6±0.4 | 37.2±1.6 | 5.6±0.2* |
| Neutrophil % | Lymphocyte % | Monocyte % | Eosinophil % | Basophil % | |
|---|---|---|---|---|---|
| Control | 13.2 ±2.2 | 74.907±6.9 | 9.3±1.9 | 1.9±2.0 | 0.8±1.2 |
| Treatment | 16.1 ±1.2 | 6.5±2.0 | 1.7±0.8 | 0.7±0.3 |
| Blood Chemistry and Liver Functions | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| ALT U/L | AST U/L | Albumin g/dL |
Alkaline Phosphatase U/L |
BUN mg/dL |
Calcium mg/dL |
Creatinine mg/dL |
Glucose mg/dL |
Phosphoru s mg/dL |
Total Bili mg/dL |
Total Protein g/dL |
|
| Control | 30.1±13 | 151.5±9 | 3.8±0.1 | 103.8±19.7 | 20.9±2.0 | 11.7±0.5 | 0.1±0.4 | 305±46 | 10.1±1.1 | 0.1±0.1 | 6.0±0.2 |
| Treatment | 49.1±17 | 133.2±51 | 3.4±0.3 | 59.9±7.3* | 35.1±7.0* | 10.6±0.6 | 0.1±0.0 | 247±37 | 8.9±0.7 | 0.1±0.0 | 5.1±0.5* |
†
Mice received five doses of either empty ND (control) or SD-ND (treatment) as described in Methods. Blood was taken five days after the final dose and analyzed by the University of California at Davis Comparative Pathology Laboratory (CPL). All results for both control and treatment groups are within the normal limits for Balb/c mice as reported by the CPL.
*
Significant differences between the two groups (p < 0.05) are designated with an asterisk. Control (n=3). Treatment (n=3).