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. 2018 Jul 16;8:10719. doi: 10.1038/s41598-018-29100-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptome analysis of intestinal LECs. The transcriptome of VECs and LECs sorted from the small intestines was analyzed (n = 3/group). (a) Hierarchical clustering using the Euclidean distance of each samples. (b) Scatter plot shows the expression levels of each entity in LECs and VECs. The list of 1226 entities that were up-regulated (fold change >5 and expression level in LECs >100; red shaded) and 975 entities that were down-regulated (fold change >5 and expression level in VECs >100; blue shaded) in LECs is shown in Supplementary Table 2. (c) Volcano plots with relative differences in expression levels between VECs and LECs and the p value of each entity. Green lines indicate fold change <0.5 or >2, and magenta lines indicate fold change <0.01 or >100 and p < 0.001. (d) A heatmap shows the expression levels of highly LEC-specific genes (fold change >100 and p < 0.001; red shaded in Fig. 3c). (e) Biological pathways from WikiPathways were assigned to each entity selected in (b). The bar charts display the negative log of the enrichment p values for each pathway enriched in LECs (red) or VECs (blue).