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. 2018 Jul 16;8:10713. doi: 10.1038/s41598-018-28281-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Neutralisation titres of serum antibodies against distinct EV71 strains. (a) TW2272/98 (C2 genogroup), (b) 200307025 (B4 genogroup), and (c) 20080738 (B5 genogroup). Sera were collected from mice at 2 weeks after the third immunisation with PBS or formalin-inactivated EV71 alone or with CpG and were serially diluted (2³–2¹²), mixed with the EV71 virus (strain TW2272/98, 200307025, or 20080738), and used to infect RD cells. After 4 days, the neutralisation titre was read as the highest dilution that resulted in the virus producing no cytopathic effect. Values shown are means ± SEMs of six mice in each experimental group; *p < 0.05. One representative study of three with similar results is shown. RD cells: rhabdomyosarcoma cells.