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. 2018 Jul 16;8:10713. doi: 10.1038/s41598-018-28281-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EV71-specific IgG antibody-secreting cells (ASCs) and IgA ASCs in mouse spleens. Mice were intranasally immunised with PBS or formalin-inactivated EV71 without/with CpG three times at 3-week intervals. Spleens were isolated at 2 weeks after the third immunisation, and the collected samples were used in EV71-specific ELISPOT assays to determine the numbers of IgG ASCs (a,b) and IgA ASCs (c,d). Values shown are means ± SEMs of six mice in each experimental group; *p < 0.05. One representative study of three with similar results is shown.