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. 2018 Jul 16;8:10709. doi: 10.1038/s41598-018-28884-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Dose response curve (based on live cell counts) for BEAS-2B cells exposed to PLACC900 from 0–750 µg/ml (n = 5). The data was fit via a sigmoidal curve using OriginPro (OriginLab Corporation) software. (b) Cellular viability (based on WST assay) for cells exposed to PLACC900 (n = 6). The symbol * indicates a significant difference between the control cells and exposed cells. The values are normalized relative to the controls. (c) Extracellular ROS of cells exposed to varying doses of PLACC900 (n = 4). The symbol * indicates a significant difference between the control cells and exposed cells. Significance was determined by one-way analysis of variance ANOVA with p < 0.05, * indicating significance.