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. 2018 Jul 16;8:10690. doi: 10.1038/s41598-018-29112-3

Figure 7.

Figure 7

Micro-computed tomography (CT) images of tertiary dentin formation 28 days after direct pulp capping using 1 µg/ml of dentin matrix components (DMCs) treated with matrix metalloproteinase (MMP)-1 (A), MMP-2 (B), MMP-3 (C), MMP-8 (D), MMP-9 (E), MMP-13 (F), MMP-20 (G), or incubated DMCs without MMP (H). The tertiary dentin area 28 days after direct pulp capping using 1 µg/ml of DMCs digested with each MMPs showed in Fig. 7I. Quantification of tertiary dentin formation induced 1 µg/ml of DMCs treated with MMP-1, -9, -13, or -20 facilitated hard tissue formation, compared with 1 µg/ml of DMCs treated with other MMPs or incubated DMCs without MMP. One microgram per millilitre of DMCs treated with MMP-20 induced a significantly thicker tertiary dentin beneath pulp capping materials. One microgram per millilitre of DMCs treated with MMP-1, -9, and -13 induced tertiary dentin with some defect or void space beneath pulp capping materials. These data represent six independent experiments. C = cavity, D = dentin, P = pulp. White arrow = dentin bridge.