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. 2018 Jul 17;4:39. doi: 10.1038/s41421-018-0047-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Summary of the base editing experiments in rats. b The representative sequence chromatogram of Hemgn targeting sequence (potential founder #1). The conversion of A to G at target site was marked with red star. c Summary of the targeted deep sequencing of on-target site for Hemgn (potential founders #1, #8, #10, and #12). The conversion efficiency of every A was indicated. The PAM was highlight in red. d The representative sequence chromatogram of Ndst4-A targeting sequence (clone #4 of potential founder #32). The conversion of T to C at target site was marked with red star. e The representative sequence chromatogram of Ndst4-B targeting sequence (clone #4 of potential founder #32). The conversion of T to C at target site was marked with red star. f Summary of the targeted deep sequencing of on-target site for Ndst4-A (potential founders #7, #15, #22, and #32). The conversion efficiency of every A was indicated. The PAM was highlight in red. g Summary of the targeted deep sequencing of on-target site for Ndst4-A (potential founders #7, #15, #22, and #32). The conversion efficiency of every A was indicated. The PAM was highlight in red