Table 2.
One-year changes in SCN parameters, in CIS patients and HCs.
| CIS patients (all) | HCs | Patients vs. HCs, estimated p-value | |
|---|---|---|---|
| 1. Measures of nodal connectivity | |||
| Mean nodal strength, estimated value (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | −3.62 (−12.29 to 2.19), p = 0.3 | −0.58 (−3.37 to 2.03), p = 0.7 | 0.50 |
| Mean clustering coefficient, estimated value (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | −0.06 (−0.19 to 0.02), p = 0.15 | −0.01 (−0.05 to 0.04), p = 0.8 | 0.30 |
| 2. Measures of nodal distance | |||
| Mean shortest path, estimated value (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | 0.36 (−0.13 to 0.89), p = 0.2 | 0.03 (−0.06 to 0.13), p = 0.6 | 0.25 |
| Global efficiency, estimated value (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | −0.05 (−0.14 to 0.02), p = 0.15 | −1.46 * 10−4 (−0.03 to 0.03), p = 0.99 | 0.20 |
| Mean local efficiency, estimated value (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | −0.06 (−0.17 to 0.01), p = 0.15 | −0.005 (−0.05 to 0.04), p = 0.9 | 0.25 |
| 3. Measures of network organisation | |||
| Modularity coefficient (bootstrap-based 95% CI), p-value | |||
| Change from baseline to 1 year | 0.02 (−0.01 to 0.06), p = 0.2 | 0.0054 (−0.03 to 0.04), p = 0.7 | 0.60 |
Comparison between CIS patients and HCs was made looking at the 95% CI. See main text for full details on the methods used. Significant p-values are indicated with bold letters. Abbreviations: CI: confidence interval; CIS: clinically isolated syndrome; FU: follow-up; HCs: healthy controls.