Table 2.
Genes differentially regulated with FDR < 0.1, when comparing Slc39a8(neo/neo) with Slc39a8(+/+) wild-type.
| Gene symbol | Official gene name | Average expression (RPKM)a | Fold-Change | log2 Fold-Change | P val | P adj |
|---|---|---|---|---|---|---|
| GD13.5 YOLK SAC | ||||||
| b Gbp1 | guanylate-binding protein 1 | 15.1 | 19.23456 | +4.265629 | 5.00E-05 | 0.070067 |
| Stc2 | stanniocalcin 2 | 28.3 | 15.36555 | 3.941627 | 1.25E-12 | 8.15E-09 |
| 2610528A11Rik | RIKEN cDNA 2610528A11 gene | 20.3 | 14.19895 | 3.827712 | 7.79E-10 | 3.05E-06 |
| Gm853 | predicted gene 853 | 17.5 | 9.210799 | 3.203326 | 1.74E-07 | 0.000487 |
| Igfbp1 | insulin-like growth factor-binding protein 1 | 248.6 | 7.475471 | 2.902165 | 2.08E-14 | 4.08E-10 |
| c Adh7 | alcohol dehydrogenase 7 (class IV), μ or σ polypeptide | 41.1 | 7.286177 | 2.865162 | 1.67E-10 | 8.20E-07 |
| c Zbtb8b | zinc-finger and BTB domain-containing 8b | 22.7 | 5.996628 | 2.584151 | 2.51E-05 | 0.037875 |
| Pkhd1l1 | polycystic kidney and hepatic disease 1-like 1 | 246.1 | 4.879078 | 2.286609 | 1.09E-12 | 8.15E-09 |
| Lancl3 | LanC lantibiotic synthetase component C-like 3 (bacterial) | 24.0 | 4.443403 | 2.151665 | 2.22E-05 | 0.037875 |
| Reln | Reelin | 63.4 | 4.442197 | 2.151274 | 7.02E-05 | 0.091747 |
| Egln3 | EGL nine homolog 3 (C. elegans) | 97.8 | 4.218064 | 2.076581 | 4.61E-09 | 1.51E-05 |
| b Hemgn | Hemogen | 56.0 | 3.825722 | +1.935732 | 5.02E-07 | 0.001095 |
| Slc30a10 | solute carrier family 30, member 10 | 38.1 | 3.592453 | +1.844969 | 2.38E-05 | 0.037875 |
| Vldlr | very-low-density lipoprotein receptor | 278.3 | 3.005814 | 1.587756 | 2.19E-07 | 0.000538 |
| b Hbb-y | hemoglobin Y, beta-like embryonic chain | 19218.6 | 0.306581 | −1.70566 | 2.09E-06 | 0.0041 |
| GD13.5 PLACENTA | ||||||
| b Hemgn | hemogen | 72.1 | 18.87205 | +4.238179 | 2.15E-06 | 0.045538 |
| b Gbp1 | guanylate-binding protein 1 | 51.3 | 5.689857 | 2.508392 | 6.52E-06 | d 0.069045 |
| GD16.5 LIVER | ||||||
| 6030408B16Rik | RIKEN cDNA 6030408B16 gene | 693.3 | 0.179781 | −2.47569 | 3.07E-06 | d 0.061137 |
| GD16.5 KIDNEY | ||||||
| NO SIGNIFICANT GENES FOUND | ||||||
| GD16.5 LUNG | ||||||
| b Afp | alpha-fetoprotein | 569.1 | 0.256586 | −1.96249 | 5.30E-06 | 0.008782 |
| Ahsg | alpha-2-HS-glycoprotein | 68.3 | 0.241724 | −2.04857 | 6.85E-07 | 0.001512 |
| Pzp | pregnancy-zone protein | 121.7 | 0.234948 | −2.08958 | 2.53E-06 | 0.005029 |
| Serpina1c | serine (or cysteine) peptidase inhibitor, clade A, member 1C | 25.8 | 0.224163 | −2.15738 | 2.67E-05 | 0.040878 |
| b Fgg | fibrinogen γ-chain | 125.3 | 0.210643 | −2.24712 | 1.10E-08 | 5.47E-05 |
| Serpina1b | serine (or cysteine) preptidase inhibitor, clade A, member 1B | 40.9 | 0.210225 | −2.24999 | 4.19E-07 | 0.001042 |
| Ttr | transthyretin | 61.2 | 0.209949 | −2.25189 | 8.56E-08 | 0.000272 |
| b Kng1 | kininogen 1 | 41.5 | 0.196759 | −2.34550 | 9.57E-08 | 0.000272 |
| b Fgb | fibrinogen β-chain | 96.2 | 0.195113 | −2.35762 | 1.06E-10 | 2.11E-06 |
| b Fga | fibrinogen α-chain | 90.3 | 0.191209 | −2.38678 | 3.55E-10 | 3.53E-06 |
| Serpina6 | serine (or cysteine) peptidase inhibitor, clade A, member 6 | 72.8 | 0.170657 | −2.55083 | 4.07E-09 | 2.70E-05 |
| b Ambp | α1-microglobulin/bikunin | 15.3 | 0.088155 | −3.50381 | 3.98E-06 | 0.007188 |
| Itih3 | inter-α trypsin inhibitor, heavy chain 3 | 25.2 | 0.084581 | −3.56353 | 2.61E-08 | 0.000104 |
| GD16.5 HEART | ||||||
| NO SIGNIFICANT GENES FOUND | ||||||
| GD16.5 CEREBELLUM | ||||||
| NO SIGNIFICANT GENES FOUND | ||||||
aRPKM, “number of Reads-Per-Kilobase-of-transcript-per-Million mapped reads”.
bGenes that are erythropoiesis- and hypoxia-related – including those involved in iron transport; these also include all platelet and white-cell types and functions because all are derived from hematopoietic stem cells.
cThese two genes encode Zn2+-containing proteins. ADH7 is an enzyme, and ZBTB8B is a Zn2+-finger TF.
dAlthough 31 genes are listed, these two are not statistically significant (i.e. P > 0.05 when Padj is taken into account).