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. 2018 Jul 10;8:227. doi: 10.3389/fcimb.2018.00227

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Copyright © 2018 Romo, Pierce, Esqueda, Hung, Saville and Lopez-Ribot.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results of Eurofin Cerep Safety-Screen 44 Panel. In vitro pharmacological profiling and assessment of the potential for off-target interactions of the 9029936 leading compound in binding screens (Eurofins Cerep-Panlabs SafetyScreen 44). The compound was screened at a 10 μM concentration in duplicate for its potential to interfere with the binding of native ligands of 44 different receptors, ion channels and enzymes. For receptor assays, compound binding was calculated as percent inhibition of the binding of a radioactively labeled ligand specific for each target. For enzyme assays, the inhibition effect was calculated as percent inhibition of control enzyme activity. Tests were performed in duplicate and results are averages of those two tests.