Table 2. Univariate and multivariate Cox regression of prognostic factors for overall survival in retinoblastoma.

Parameter	Univariate analysis			Multivariate analysis
	HR	95%CI	P	HR	95%CI	P
Age (years)	0.876	0.463–1.659	0.685
≤14 vs >14
Gender	0.932	0.486–1.788	0.833
Male vs Female
Size	3.468	1.531–7.857	0.003	1.203	0.406–3.569	0.739
≤10 mm vs >10 mm
Choroidal invasion	4.237	2.077–8.640	<0.001	1.750	0.733–4.182	0.208
Absent vs Present
Optic nerve invasion	2.759	1.436–5.301	0.002	2.001	0.951–-4.210	0.068
Absent vs Present
Laterality	1.177	0.567–2.441	0.662
Unilateral vs Bilateral
Pathologic grade	0.744	0.387–-1.431	0.376
Well vs Poor
LncRNA AFAP1-AS1	5.173	2.566–10.429	<0.001	3.598	1.332–9.718	0.012
Low vs High

Abbreviations: 95% CI, 95% confidence interval; HR, hazard ratio