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. 2018 May 15;38(3):BSR20170939. doi: 10.1042/BSR20170939

Figure 2. UA exacerbates morphological damage in rats with MCAO.

Figure 2

UA exacerbated morphological damage in rats with MCAO in a dose-dependent manner. Aorta was separated and was fixed in formalin, then was embedded in paraffin, and sliced into 5-μm-thick sections. Sections were stained with HE and visualized under a microscope (Leica DM 2500). Rats were received an intragastric administration of UA at 50, 100, 150, and 200 mg/kg body weight twice one day for 12 weeks consecutively (n = 11 in each group). Rats treated with normal saline were used as the control group (MCAO + saline). a and b in Sham group indicates internal elastic membrane and smooth muscle cell. The arrow in MCAO + UA (200 mg/kg) and MCAO + UA (400 mg/kg) groups indicate foam cells.