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Patients with the PLS3 duplication. Thoracic radiographs of the index patient before bisphosphonate treatment at age 11 years (A), and after 2 years of bisphosphonate treatment at 13 years (B) showing multiple compressed vertebrae and improvement in vertebral shape after bisphosphonate treatment. The mutation-positive mother at 40 years (C) and younger brother at 6 years (D) also had compression fractures. Pedigree of the family (E).
