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. 2018 Jul 10;8:238. doi: 10.3389/fcimb.2018.00238

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Copyright © 2018 Wang, Hussain, Yue, Liao, Li, Yao, Song, Sun, Wang, Xu, Sreevatsan, Zhao and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The inhibitory effect on autophagy by miR-199a was confirmed by Transmission Electron Microscopy (TEM). J774a.1 cells were transfected with control, miR-199a mimic or siTBK1 for 24 h, and then infected with M. bovis at an MOI of 10 for 24 h. (A) Close-up images (× 4,0000 magnification) of cytoplasmic regions containing autophagosomes (denoted by white arrowheads). (B) The number of autophagosomes per cross-sectioned cell was counted (20 cells per group counted by TEM). Data is presented as mean ± SD in three independent experiments (**P < 0.01).