Table 7.
Areas of significantly decreased and increased connectivity in patients with ASD in comparison with a group of healthy individuals.
| Seed region | Voxels | Area | Side | T score | MNI Coordinates |
|---|---|---|---|---|---|
| AREAS OF DECREASED FUNCTIONAL CONNECTIVITY IN PATIENTS WITH ASD | |||||
| PCC* | 47 | Middle temporal gyrus | Left | 4.66 | −54 5 −26 |
| PCC | 56 | Cuneus | Right | 4.64 | 15 −70 25 |
| PCC | 83 | Inferior frontal gyrus | Left | 4.49 | −39 17 −26 |
| PCC | 35 | Posterior cingulate | Left | 4.25 | −6 −55 28 |
| PCC | 33 | Superior frontal gyrus | Left | 4.01 | −21 59 25 |
| PCC | 20 | Caudate | Right | 3.82 | 3 2 −2 |
| PCC | 14 | Cerebellum, Posterior lobe | Right | 3.70 | 45 −37 −44 |
| PCC | 12 | Anterior cingulate | Left | 3.50 | −6 44 13 |
| Left amygdala | 44 | Insula | Right | 4.47 | 36 2 13 |
| Left amygdala | Claustrum | Right | 3.57 | 27 8 19 | |
| Left amygdala | 172 | Inferior parietal lobule | Right | 4.30 | 53 −31 22 |
| Left amygdala | Postcentral gyrus | Right | 3.83 | 53 −19 13 | |
| Left amygdala | 44 | Cingulate gyrus | Right | 4.20 | 30 −34 40 |
| Left amygdala | 33 | Precentral gyrus | Right | 4.08 | 36 −4 55 |
| Left amygdala | 21 | Inferior frontal gyrus | Right | 3.89 | 54 11 25 |
| Left Amygdala | 44 | Middle frontal gyrus | Right | 3.88 | 3 −16 52 |
| Left Amygdala | 12 | Postcentral gyrus | Left | 3.44 | −57 −15 43 |
| Left ant. frontal | 15 | Superior frontal gyrus | Right | 3.61 | 9 41 55 |
| Left ant. hippocampus | 84 | Superior temporal gyrus | Left | 4.20 | −54 −28 4 |
| Left ant. hippocampus | Transverse temporal gyrus | Left | 4.03 | −54 −19 10 | |
| Left ant. hippocampus | 54 | Superior temporal gyrus | Right | 4.08 | 66 −19 10 |
| Anterior hippocampus | 33 | Insula | Right | 3.92 | 36 −28 13 |
| Left ant. hippocampus | 12 | Precentral gyrus | Left | 3.66 | −54 −1 10 |
| Left ant. hippocampus | 10 | Inferior frontal gyrus | Right | 3.51 | 66 14 28 |
| Left temporal pole | 50 | Postcentral gyrus | Left | 4.31 | −27 −28 67 |
| Left temporal pole | Inferior parietal lobule | Left | 3.45 | −30 −34 58 | |
| Left temporal pole | 34 | Middle temporal gyrus | Left | 4.25 | −57 −10 −11 |
| Left temporal pole | 34 | Cerebellum, Anterior lobe | Right | 4.25 | 30 −40 −20 |
| Left temporal pole | Parahippocampal gyrus | Right | 3.49 | 27 −25 −20 | |
| Left temporal pole | 28 | Medial frontal gyrus | Right | 4.25 | 12 −19 58 |
| Left temporal pole | 47 | Superior temporal gyrus | Left | 4.14 | −48 8 −32 |
| Left temporal pole | 68 | Postcentral gyrus | Right | 4.00 | 63 −10 31 |
| Left temporal pole | 22 | Superior temporal gyrus | Right | 3.84 | 42 17 −38 |
| Left temporal pole | 72 | Posterior cingulate | Right | 3.83 | 3 −52 22 |
| Left temporal pole | 28 | Cuneus | Right | 3.83 | 21 −76 28 |
| Left temporal pole | Precuneus | Right | 3.57 | 24 −67 25 | |
| Left temporal pole | 20 | Middle frontal gyrus | Right | 3.74 | 63 8 37 |
| Left temporal pole | 11 | Postcentral gyrus | Left | 3.69 | −54 −4 13 |
| AREAS OF SIGNIFICANTLY INCREASED FUNCTIONAL CONNECTIVITY IN PATIENTS WITH ASD | |||||
| PCC | 22 | Caudate | Left | 4.13 | −18 −16 25 |
| PCC | 10 | Middle frontal gyrus | Right | 3.60 | 45 8 61 |
| Left amygdala | 28 | Superior frontal gyrus | Right | 4.78 | 15 53 28 |
| Bil. medial frontal region | 74 | Postcentral gyrus | Right | 4.04 | 63 −7 13 |
| Bil. medial frontal region | Precentral gyrus | Right | 3.51 | 54 −4 31 | |
| Bil. medial frontal region | 32 | Precentral gyrus | Left | 3.40 | −51 −10 25 |
| Bil. medial frontal region | Postcentral Gyrus | Left | 3.29 | −60 −7 22 | |
*
PCC, Posterior Cingulate Cortex bilaterally (posterior aspect of the DMN). Ant, anterior; Bil, Bilateral; All regions in the table had p < 0.001 (two-sample t-test), cluster with at least 10 voxels.