Table 8.

Sub-regional overlap of abnormalities across structural and functional MRI modalities.

Lobe/Region	Area	GM/VBM		Cortical Thickness				Cortical Surf. area				Gyrification Index				FC of DMN
				FS-VxV		FS-ROI		FS-VxV		FS-ROI		FS-VxV		FS- ROI
		Left	R	Left	R	Left	R	Left	R	Left	R	Left	R	Left	R	Left	R
Frontal	Orbito-Frontal					↑	↑	↑
	Cingulate	↓	↓		↓	↓	↑	↑	↑		↑					$\downarrow$ $\uparrow$	↓
	Sup. Frontal		↓	↓	↓			↑	↑							↓	$\downarrow$ $\uparrow$
	Middle Frontal		↓	↓				↑	↑						↑		$\downarrow$ $\uparrow$
	Inf. Frontal/Pars triang.								↑							↓	↓
	Frontopolar														↑
Temporal	Pole	↓				↓										↓
	Sup. Temp. sulcus/G.	↓		↓			↓	↑								↓	↓
	Middle Temp. G.	↓			↓			↑	↑				↑			↓	↓
	Inf. Temp. G							↑	↑
	Fusiform G	↓
	Parahippocampus	↓														↓
	Amygdala	↓														↓	↓
	Hippocampus															↓
	Insula							↑									↓
	Claustrum	↓
	Caudate															↑	↓
Central	Paracentral	↓		↓		↓	↓		↑			↑		↑
	Precentral			↓	↓			↑	↑			↑		↑	↑	$\downarrow$ $\uparrow$	↓ $\uparrow$
	Postcentral	↓		$\downarrow$ $\uparrow$	↓			↑						↑	↑	$\downarrow$ $\uparrow$	$\downarrow$ $\uparrow$
Parietal	Supramarginal			↓					↑					↑	↑
	Sup. parietal			↓	↓								↑	↑	↑
	Inf. Parietal			↓	↓			↑								↓	↓
	Precuneus			↓				↑	↑				↑
Occipital	Lingual G.			↓									↑
	Lateral Occip.								↑
	Cuneus																↓
Cerebellum	↓	$\downarrow$ $\uparrow$														↓	↓

$\downarrow$, Decreased $\uparrow$, increased. GM, gray matter; VBM, voxel-based morphometry; FS-VxV, FreeSurfer voxel by voxel analyses; FS-ROI, FreeSurfer voxel region of interest (ROI) analyses; FC, functional connectivity; DMN, default mode network, G, gyrus.