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. 2018 Jul 10;9:365. doi: 10.3389/fendo.2018.00365

Figure 1.

Figure 1

Thymus atrophy and microenvironmental alterations in the absence of galectin-3. (A) Shows comparative thymus pictures of WT and Gal-3−/− mice. Thymus mass (B) and cellularity (C) of Gal-3−/− mice are shown in comparison to WT control mice. Hematoxylin & Eosin stained sections of thymus of WT (D,F) and Gal-3−/− (E,G) mice. Presence of concentric Hassall body-like structures is shown in Gal-3−/− thymus (white arrow in G) but not in WT mice (F). Immunofluorescence staining with anti-pan-cytokeratin is shown in the thymus of WT (H,J) and Gal-3−/− (I,K) mice. Inserts in (H,J) show negative controls. Asterisks in (I,K) denote DAPI stained TEC-free regions. Blue staining in panels: DAPI, used to show cell nuclei. Images are representative of 5 animals/group. Bar in (A): 0.25 cm. C, Cortex; M, Medulla.