Figure 3.

(A) Overview of the plasmid pEsco-36073cz. The innermost circles show the main regions of the plasmids. Similarities with other plasmids are shown in the next circle; each color represents a unique plasmid. In the outer circle, indicative genes and the direction of transcription are shown by arrows. Replicons of the plasmid are indicated as pink arrows. Genes responsible for plasmid transfer and maintenance are shown in green and orange, respectively. (B) Linear map of the ARI-A resistance island of the plasmid pEsco-36073cz. Arrows show the direction of transcription of open reading frames (ORFs), while truncated ORFs appear as rectangles (arrows within rectangles indicate the direction of transcription). bla_NDM-like genes are shaded purple, while other resistance genes are shown in red. IS elements and transposases are shown in yellow and green, respectively. intI1 genes are shaded blue; teal blue arrow indicates the group II intron. The remaining genes are shown in white. Thin lines below the map correspond to highly similar sequences from other plasmids.