Table 6.
Frequencies of alleles and genotypes of rs1805010, rs1801275, and rs2107356 in MG subgroups of a new classification and the control group [case (%)].
| HC | Juvenile (< 15) | Adult (≥15) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Thymoma | Non-thymoma | ||||||||||
| AchRAb (−) | AchRAb (+) | ||||||||||
| 15–50 | >50 | Ocular | Generalized | ||||||||
| Number | 487 | 71 | 409 | 104 | 300 | 84 | 204 | 126 | 78 | 135 | 67 |
| rs2107356 | 484* | 68 | 395 | 99 | 291 | 81 | 198 | 123 | 75 | 133 | 63 |
| CC | 200 (41.3) | 29 (42.6) | 145 (36.7) | 30 (30.3) | 114 (39.2) | 29 (35.8) | 79 (39.9) | 52 (42.3) | 27 (36.0) | 57 (42.9) | 19 (30.2) |
| CT | 214 (44.2) | 32 (47.1) | 190 (48.1) | 43 (43.4) | 144 (49.5) | 40 (49.5) | 98 (49.5) | 58 (47.2) | 40 (53.3) | 58 (43.6) | 37 (58.7) |
| TT | 70 (14.5) | 7 (10.3) | 60 (15.2) | 26 (26.3) | 33 (11.3) | 12 (14.8) | 21(10.6) | 13 (10.6) | 8 (10.7) | 18 (13.5) | 7 (11.1) |
| T allele | 0.37 | 0.34 | 0.39 | 0.48a | 0.36b | 0.40 | 0.35 | 0.34 | 0.37 | 0.35 | 0.40 |
| rs1805010 | 487 | 70 | 405 | 103 | 297 | 84 | 201 | 126 | 75 | 134 | 66 |
| GG | 135 (27.7) | 21 (30.0) | 106 (26.2) | 20 (19.4) | 85 (28.6) | 18 (21.4) | 60 (29.9) | 42 (33.3) | 18 (24.0) | 38 (28.4) | 13 (19.7) |
| GA | 233 (47.8) | 27 (38.6) | 195 (48.1) | 43 (41.7) | 150 (50.5) | 42 (50.0) | 103 (51.2) | 58 (46.0) | 45 (60.0) | 65 (48.5) | 35 (53.0) |
| AA | 119 (24.4) | 22 (31.4) | 104 (25.7) | 40 (38.8) | 62 (20.9) | 24 (28.6) | 38 (18.9) | 26 (20.6) | 12 (16.0) | 1 (23.1) | 18 (27.3) |
| A allele | 0.48 | 0.51 | 0.50 | 0.60c | 0.46d | 0.54 | 0.45 | 0.44 | 0.46 | 0.47 | 0.43 |
| rs1801275 | 487 | 69 | 402 | 101 | 296 | 83 | 201 | 126 | 75 | 133 | 66 |
| AA | 348 (71.5) | 51 (73.9) | 254 (63.2) | 63 (62.4) | 189 (63.9) | 57 (68.7) | 122 (60.7) | 77 (61.1) | 45 (60.0) | 86 (64.7) | 39 (59.1) |
| GA | 131 (26.9) | 17 (24.6) | 139 (34.6) | 36(35.6) | 100(33.8) | 25(30.1) | 73 (36.3) | 45 (35.7) | 28 (37.3) | 47 (35.3) | 24 (36.4) |
| GG | 8 (1.6) | 1 (1.4) | 9 (2.2) | 2(2.0) | 7(2.4) | 1 (1.2) | 6 (3.0) | 4 (3.2) | 2 (2.7) | 0 (0) | 3 (4.5) |
| G allele | 0.15 | 0.14 | 0.20 | 0.20 | 0.19 | 0.17 | 0.21e | 0.21 | 0.21 | 0.18 | 0.23 |
Italic bold refers to the number of successfully genotyped patients with adequate clinical data in each group.
. adult thymoma MG vs. HC, P = 0.003, OR = 1.600 (1.176-2.177), PBon = 0.018
codominant model, adult thymoma MG vs. HC, P = 0.0056
additive model, adult thymoma MG vs. HC, P = 0.0017
. adult thymoma MG vs. adult non-thymoma MG, P = 0.003, OR = 1.634 (1.179–2.264), PBon = 0.018
codominant model, adult thymoma MG vs. non-thymoma MG, P = 0.0025
additive model, adult thymoma MG vs. non-thymoma MG, P = 0.0032
. adult thymoma MG vs. HC, P = 0.003, OR = 1.583 (1.166–2.148), PBon = 0.018
codominant model, adult thymoma MG vs. HC, P = 0.0034
additive model, adult thymoma MG vs. HC, P = 0.0013
. adult thymoma MG vs. adult non-thymoma MG, P = 0.001, OR = 1.731 (1.255–2.388), PBon = 0.006
codominant model, adult thymoma MG vs. non-thymoma MG, P = 0.0025
additive model, adult thymoma MG vs. adult non-thymoma MG, P = 0.0012
. adult non-thymoma AChR-Ab positive MG vs. HC, P = 0.006, OR = 1.509 (1.121-2.030), PBon = 0.036
codominant model, adult non-thymoma AChR-Ab positive MG vs. HC, P = 0.011
additive model, adult non-thymoma AChR-Ab positive MG vs. HC, P = 0.0026.